Oral hydrogen water prevents chronic allograft nephropathy in rats
نویسندگان
چکیده
منابع مشابه
Oral hydrogen water prevents chronic allograft nephropathy in rats.
Reactive oxygen species (ROS) contribute to the development of interstitial fibrosis and tubular atrophy seen in chronic allograft nephropathy (CAN). As molecular hydrogen gas can act as a scavenger of ROS, we tested the effect of treatment with hydrogen water (HW) in a model of kidney transplantation, in which allografts from Lewis rats were orthotopically transplanted into Brown Norway recipi...
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OBJECTIVES Our previous study demonstrated that Ligustrazine reduced renal dysfunction associated with ischemia-reperfusion injury in mice. In this study, we investigated whether Ligustrazine herbal injection had any preventive and therapeutic effectiveness against chronic allograft nephropathy in rats. METHODS Male Lewis rats that received left renal grafts from male Fisher 344 rats were ran...
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Since the first successful kidney transplantation in 1954 between Identical twins, a new modality to treat patients with terminal kidney insufficiency was born. Although the results in the first decades were modest, continuous development has characterized this captivating field. A major advance was the introduction of the new immunosuppressant cyclosporine A in the early 1980s. The fundament o...
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Chronic renal allograft disease remains a leading cause of graft loss. Immunologic and non-immunologic risk factors are related to its development and may be present before or develop after transplantation. Histological evaluation of renal tissue has an important role in the management, especially for the evaluation of immune activity against the graft and toxicity of immunosuppressive drugs. M...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2010
ISSN: 0085-2538
DOI: 10.1038/ki.2009.421